Is LEX™ soluble with water?

No. Pure water has a too low ionic strength and will precipitate LEX®. We recommend using PBS or similar salt solution at neutral pH of 7.4. If water is used, titrate the water to a pH above 8 as LEX® is soluble in water with pH above 8.

Is LEX™ stable at room temperature?

Yes, LEX® is stable at RT for 24 h; thereafter the collagen boosting activity will be gradually lost. It is recommended to formulate LEX® directly after thawing.

How long can I store frozen LEX™?

LEX® is very stable at -20 °C or lower and can be stored for year; however, we recommend using LEX within one (1) year after quality testing. The retest date is subject to retesting of the product’s quality.Our data shows excellent collagen boosting effect on fibroblasts after 55 months storage.

Can I add preservatives to LEX™?

Yes, no problem. We have not tested all preservatives, but the most commonly used ones should be fine.

What is the optimal pH for cosmetic formulations with LEX®?

In formulation, however, LEX® is stable in commercialized products (creams) at pH around 5.5. This applies to creams, pH in serum with LEX® is not tested by Regenics.

How to formulate LEX® in cosmetic bases?

Add LEX® as the last step of the procedure; do not heat above 60°C.

Can I use alcohol in my LEX® formulation?

No, high concentrations of alcohols will precipitate LEX®.

What is the optimal concentration of LEX® in a cosmetic formulation?

5%. Regenics’ published clinical data show that 5% in formulation significantly reduces fine lines and wrinkles and redness, fades discoloration, enhance hydration and brightness of the skin as well as improves global skin appearance (Lønne et al, Int J Cosmet Sci. 2013 Oct;35(5):515-22). The study shows significant discoloration fading at 1% LEX®.

What is glycerol-stabilized LEX® compared to concentrated LEX®?

Glycerol-stabilized LEX® is solution consisting of 33% LEX® in a phosphate buffered saline/glycerol solution; 33% phosphate buffered saline, 28% glycerol. Glycerol stabilizes LEX® components and glycerol-stabilized LEX® therefore has increased storage stability. While pure LEX® is stable for one week at 4°C, glycerol-stabilized LEX® is stable for 2 weeks at 4°C.

Why is LEX® shipped with frozen (dry ice or ice blocks)?

LEX® is shipped frozen to keep the product fresh and secure biological activity. Pure LEX® is shipped frozen on dry ice as it is absolutely essential that it is kept frozen during shipment. As glycerol-stabilized LEX® is more stable, it is shipped frozen on ice blocks to keep it frozen or refrigerated.

What type of container should I use for a LEX® cosmetic?

We recommend airtight containers for improved freshness and stability. Airtight containers will reduce oxidation of fatty acids in LEX®. This applies particularly to less fatty formulations such as serum, eye creams and light day creams. For more fatty formulations such as night cream, jars are suitable.

Does LEX® smell like fish?

No. LEX® does not smell like fish itself nor in formulation if formulated correctly. LEX® has a very weak sweet smell, and does not need any covering fragrances if formulated correctly. If formulated incorrectly allowing fatty acids to be oxidized, an odor associated with rancid fat may develop.

Why has LEX® an orange color?

-LEX® contains the powerful antioxidant astaxanthin which has a deep red/orange color.

What if I spill LEX®?

Do not clean with pure water; pure water will precipitate LEX® and LEX® proteins will stick to the surface. Wipe off with paper and paper soaked in saltwater. When all LEX® is removed, clean according to your general cleaning procedure.

Can I freely use the published science data for LEX®?

No, you can only formulate claims based on the published science for LEX® if the final percentage of LEX® in your formulation is the same as used in the clinical study. This restriction in claim generation is regulated by the EU commission. Moreover, the published data is copyright-protected; thus, figures cannot be reprinted without permission.

Is LEX® made from a living organism?

No, LEX® is made from unfertilized salmon roe; meaning there is no life.

What is the INCI name of LEX®?

Roe extract. The INCI name is unique for LEX®.

Does LEX® have an INCI name in China?

Yes, roe extract is registered in China. The INCI name is unique for LEX®.

What brands are on the market containing LEX®?

-Aqua Derma (ORKLA, Scandinavia), Cuvget, to name a few.

Do I need an import or customs clearance to get LEX®?

-Depending on your local import regulations, you may need to apply for import permit. LEX® is a biological product of fish origin. Please check the import regulations with your local custom office.

Can I get LEX® for cosmetics from other sources?

No, salmon roe extract is patented by Regenics. Regenics owns all intellectual property rights for use of salmon roe extracts in cosmetics for treatment of skin lesions. Regenics has 6 granted and 12 pending patents worldwide.

What are the main claims for LEX®?

LEX®: reduces fine lines and wrinkles, fades discoloration, reduces skin redness, improves skin lightness, increases skin hydration, improves global skin appearance, revitalizes the skin's own cells, is a collagen booster, promotes elastin production, increases skin cell mobility, contains skin penetration enhancers, causes no adverse skin reactions.

What are CoA specs of each LEX® shipment?

All batches of LEX® are quality assured for content, microbiology and biological activity. The specifications are indicated in the CoA that follows each batch and shipment. For biological activity, collagen secretion from human skin fibroblast is more than 2-fold increased compared to control conditions.

How can I order a LEX® sample?

- Shipments take usually 2-3 days for international orders and 1-2 days for local destination. We dispatch orders usually on Monday or Tuesday to avoid weekends and unnecessary extension of delivery time. To order a LEX® sample is very easy. Please use our online order page.

Regenics AS has developed a number of assays and techniques to study effects of various substances on skin cells both in vitroin vivo and in the clinic. Our focus is to develop products and techniques for therapeutic skin applications and to improve skin appearance.