ReGenics News

New publication details development of Collex

We are very happy to announce our latest publication in high-ranked journal Polymers. The article details the development and technical details of Collex, our marine, advanced hydrogel dressing, and follows the publication earlier this year showing accelerated healing and reduced inflammation in Collex-treated wounds. The development has been done in collaboration with our excellent partners at RISE Research Institutes of Sweden.

In the article, we describe the development of an all-marine bio-ink suitable for 3D printing, consisting of alginate, nanocellulose and our HTX salmon roe extract. A formulation with optimal viscosity (Pa.s) and shear stress (Pa) for 3D printing was found, crosslinked with calcium to form Collex, a solid hydrogel patch. The patch exhibited impressive mechanical properties, durability and suitability for wound dressing applications. In addition, Collex showed an optimal release profile, releasing the key bioactive component HTX into the surrounding media.

We further highlight crucial biocompatibility measures such as sterility, chemical characterization, toxicological evaluation, and cytotoxicity. Additionally, we show Collex and HTX's collagen-boosting effects. This supplements our previous publication, Gilljam et al., 2023, demonstrating anti-oxidative and anti-inflammatory properties.

Together, these publications provide strong evidence for the effectiveness and potential of Collex to revolutionize the treatment of challenging wounds.

Huge thanks to authors and partners: Patrik Stenlund, Linnea Enstedt, Karin Gilljam, Simon Standoft, Astrid Ahlinder, Maria Lundin Johnson, Henrik Lund, Anna Millqvist Fureby, Mattias Berglin

Norges forskningsråd Formas, a Swedish Research Council for Sustainable Development Scantox Group Innovation Norway Forskningsparken - Oslo Science Park ShareLab Ocean TuniCell AS BlueBio Cofund